Index · Artikel · Two-step vaccine may offer "universal" flu jab

Two-step vaccine may offer "universal" flu jab

2010-07-16 3
   
Advertisement
résuméWASHINGTON A two-step flu vaccine using DNA to "prime" the immune system and then a traditional seasonal influenza vaccine may be able to protect against all strains of the virus -- providing a long-sought "universal" flu vaccine, U.S.
Advertisement

Two-step vaccine may offer "universal" flu jab


WASHINGTON A two-step flu vaccine using DNA to "prime" the immune system and then a traditional seasonal influenza vaccine may be able to protect against all strains of the virus -- providing a long-sought "universal" flu vaccine, U.S. researchers said on Thursday.

The team at the National Institute of Allergy and Infectious Diseases is already testing the new vaccine in people and says the results of tests in mice, ferrets and monkeys suggest the industry may finally be able to dump the cumbersome process of making fresh flu vaccines every year.

"This is the first step, conceptually, toward a good shot at a universal vaccine," NIAID Director Dr. Anthony Fauci said in a telephone interview.

Every year, the influenza strains that are circulating mutate a little bit and at any given time several very different strains are infecting people. In some years a new mutant pops up -- such as the new H1N1 swine flu strain that appeared in March 2009 to spark a pandemic.

Vaccine makers have to change their formulations every year to match the current strains. To make matters worse, virtually all flu vaccines are made using decades-old technology based on chicken eggs that is both slow and prone to contamination.

So the goal is to come up with a universal influenza vaccine that could protect people from all flu strains for decades or even for life.

NIAID's Dr. Gary Nabel said his lab has taken a big step toward this goal. Their method, described in the journal Science, starts with a piece of DNA based on the hemagglutinin protein -- a mushroom-shaped structure on the outside of the virus that gives flu strains the "H" in their names.

The DNA directs the body to make antibodies against a part of the flu virus that is normally hidden -- on the "stem" of the hemagglutinin protein. This part is conserved, meaning it does not change from flu strain to flu strain.

OLD AND NEW STRAINS

Vaccinated mice and ferrets produced antibodies that protected them against flu strains from 1934 through 2007.

"We are excited by these results," Nabel said. "The prime-boost approach opens a new door to vaccinations for influenza that would be similar to vaccination against such diseases as hepatitis, where we vaccinate early in life and then boost immunity through occasional, additional inoculations in adulthood."

The vaccine, which uses DNA from Netherlands-based Crucell NV, "looks pretty safe," Fauci said. "They are already well into, at least a full year into, a Phase 1 trial."

Such trials are meant to see if a new drug or vaccine is safe in people. A larger, Phase 2 trial could start next year, Fauci said.

Seasonal influenza kills 250,000 to 500,000 people a year globally, including 36,000 in the United States. Pandemics often kill more and while H1N1 has not been especially deadly, it has killed far more children, young adults and pregnant women than seasonal flu usually does.

The experimental vaccine protected animals against H5N1 bird flu, as well. While avian influenza only rarely infects people, it has killed 296 of the 500 sickened by it since 2003.

Flu experts fear H5N1 could mutate and cause a pandemic far worse than swine flu and, using current vaccine technology, it will take months to formulate a good vaccine against it. Swine flu made its spread global within six weeks.

Dozens of companies make influenza vaccines, including Sanofi Aventis, GlaxoSmithKline, Novartis, AstraZeneca and CSL.

(Editing by Eric Walsh)

  • Two-step vaccine may offer "universal" flu jab

    Two-step vaccine may offer "universal" flu jab
    WASHINGTON A two-step flu vaccine using DNA to "prime" the immune system and then a traditional seasonal influenza vaccine may be able to protect against all strains of the virus -- providing a long-sought "universal" flu vaccine, U.S.
    2010-07-16 FLUVACCINE
  • Researchers take step to 'universal' flu vaccine

    Researchers take step to 'universal' flu vaccine
    WASHINGTON A "headless" version of the influenza virus protected mice from several different strains of flu and may offer a step toward a so-called universal flu vaccine, researchers reported on Tuesday. They identified a piece of the virus that
    2010-05-25 FLUVACCINE
  • Asia way short of vaccine to fight swine flu: WHO

    Asia way short of vaccine to fight swine flu: WHO
    HONG KONG Asia is going to be way short of the new H1N1 vaccine to fight swine flu when the next surge of infections hits during the cold season this year, a spokesman for the World Health Organization said on Tuesday. Australia and China are due to
    2009-08-25 FLUASIA
  • Fewer than a third in U.S. would get swine flu jab

    Fewer than a third in U.S. would get swine flu jab
    WASHINGTON Fewer than a third of U.S. adults would get a shot especially made to protect against the new H1N1 swine flu virus, according to a poll released on Thursday. Most are simply not that worried about the new flu, which has spread around the g
    2009-05-14 FLUVACCINEPOLL
  • California boy who beat leukemia urges near-universal measles jabs

    California boy who beat leukemia urges near-universal measles jabs
    n">A 7-year-old cancer survivor has made a public plea in Northern California for near-universal measles vaccinations, following a rare outbreak of the contagious disease that began in December at the Disneyland resort. Elementary school student R
    2015-02-12 USASCHOOLSMEASLES
  • Early vaccination tied to fewer flu symptoms for health workers

    Early vaccination tied to fewer flu symptoms for health workers
    n">(Reuters Health) - For health care providers, earlier influenza vaccination is linked to fewer flu symptoms and less time away from work, a Mexican study suggests. "It's a straightforward phenomenon: it takes three weeks for antibodies to
  • Insight: U.S. government investment gives flu vaccines a shot in the arm

    Insight: U.S. government investment gives flu vaccines a shot in the arm
    CHICAGO Fighting the flu may soon get easier. As early as next year, more modern and more effective vaccines will hit the market, thanks to investments by the U.S. government and pharmaceutical companies. And even bigger scientific advances are expec
    2013-01-19 FLUVACCINES
  • Universal free flu shots curb antibiotic use

    Universal free flu shots curb antibiotic use
    NEW YORK (Reuters Health) - When the Canadian province of Ontario began offering free flu vaccinations to its entire population in 2000, the result was a dramatic decrease in influenza-associated antibiotic prescriptions. Dr. Fawziah Marra, of the Un
    2009-08-20 FLUSHOTS
  • People will fear flu vaccine "adverse events": study

    People will fear flu vaccine "adverse events": study
    WASHINGTON Fear of adverse events such as miscarriages, rare neurological conditions and ordinary heart attacks will discourage some people from participating in mass vaccination efforts to fight swine flu, but public health experts said on Friday th
    2009-10-30 FLUVACCINEEVENTS
  • New seasonal flu vaccine to contain H1N1 strain

    New seasonal flu vaccine to contain H1N1 strain
    GENEVA This year's seasonal flu vaccine in the northern hemisphere should include protection against three strains, including the pandemic H1N1 virus, the World Health Organization (WHO) recommended on Thursday. The composition, announced after a fou
    2010-02-18 FLUWHO
  • Flu "super antibody" may bring universal shot closer

    Flu "super antibody" may bring universal shot closer
    LONDON Scientists have found a flu "super antibody" called FI6 that can fight all types of influenza A viruses that cause disease in humans and animals and say their discovery may be a turning point in the development of new flu treatments. Rese
    2011-07-28 FLUANTIBODY
  • In U.S., flu vaccine worked in just over half of those who got it

    In U.S., flu vaccine worked in just over half of those who got it
    CHICAGO A U.S. government analysis of this season's flu vaccine suggests it was effective in only 56 percent of people who got the shot, and it largely failed to protect the elderly against an especially deadly strain circulating during flu season. T
    2013-02-21 FLUVACCINEUSA
  • CDC says it is too late to make new flu vaccine for this season

    CDC says it is too late to make new flu vaccine for this season
    n">The U.S. Centers for Disease Control and Prevention said on Thursday it is too late to make new flu vaccines for the current flu season that could better protect against the predominant flu virus now circulating in the United States. On Wednesd
    2014-12-04 FLUCDCUSA
  • New flu "unstoppable", WHO says, calls for vaccine

    New flu "unstoppable", WHO says, calls for vaccine
    WASHINGTON Saying the new H1N1 virus is "unstoppable", the World Health Organization gave drug makers a full go-ahead to manufacture vaccines against the pandemic influenza strain on Monday and said healthcare workers should be the first to get
    2009-07-13 FLU
  • Experts hope H1N1 will spur effort on universal jab

    Experts hope H1N1 will spur effort on universal jab
    LONDON The H1N1 swine flu pandemic should spur pharmaceutical researchers to renew efforts to develop a universal flu vaccine and rethink ways of dealing with future pandemics, scientists said on Friday. Flu experts from the World Health Organization
    2009-10-02 FLUVACCINEUNIVERSAL
  • U.S. school swine flu event shows vaccine challenge

    U.S. school swine flu event shows vaccine challenge
    LANDOVER, Maryland A U.S. government media event to promote H1N1 school vaccinations on Friday included VIPs, cute kids and a phalanx of television cameras -- but only one in five children at the school had proper parental consent to get immunized. "
    2009-10-09 FLUUSASCHOOLS
  • Everyone in U.S. should get flu vaccine: experts

    Everyone in U.S. should get flu vaccine: experts
    WASHINGTON Everyone in the United States over the age of six months should get seasonal influenza vaccines every year, federal vaccine advisers said on Wednesday. The Advisory Committee on Immunization Practices made the long-awaited vote to recommen
    2010-02-25 FLUUSA
  • Giving flu vaccine to tots cuts ER visits

    Giving flu vaccine to tots cuts ER visits
    n">Recommending that all U.S. preschoolers get a flu shot cut visits to the emergency department for flu-like illness by more than a third, U.S. and Canadian researchers said on Monday in a study that showed the direct impact of vaccination policy
    2011-09-19 FLUCHILDRENUSA
  • Flu vaccine not linked to fetal death

    Flu vaccine not linked to fetal death
    NEW YORK (Reuters Health) - Getting the flu vaccine while pregnant does not increase the odds that the fetus will die in the womb, according to a new study of tens of thousands of women in Norway. Although fetal deaths were rare during the study, the
    2013-01-16 FLUVACCINE
  • Protection offered by GSK malaria vaccine fades over time

    Protection offered by GSK malaria vaccine fades over time
    LONDON/NEW YORK The effectiveness of an experimental malaria vaccine developed by GlaxoSmithKline wanes over time, with the shot protecting only 16.8 percent of children over four years, according to trial data. The disappointing results for RTS,S -
    2013-03-20 VACCINEMALARIAGSK

TOP

  • Day/
  • Week/
  • Original/
  • Recommand

Updated

  • Fruit zerbröckelt: The Lazy Man Pie

    Fruit zerbröckelt: The Lazy Man Pie
    Foto von Maria Robledo Um zu versuchen , zwei Varianten der Pflaume-Himbeer - Crumble, klicken Sie hier für die Rezepte. Fruit zerbröselt sind die faulen Mann Pie: Nichts mehr als Obst gebacken mit einer knusprigen, buttrig Topping aus Zucker, Mehl,
  • Tagamet - wie offten können Sie Tagament nehmen?

    Ich nahm eine etwa 8 Stunden und bekommen Säure wieder wäre es sicher eine andere zu übernehmen? ----schneiden---- In Antwort auf die Marvell bei 2012-03-24 03.48 Ich weiß, diese Antwort ist sehr, sehr spät ... aber kann jemand helfen. Die Dosis von
  • Zurück zu, wo ich begonnen

    Ich tat ziemlich gut auf mich von meinem Schmerz Meds Entwöhnung, aber jetzt habe ich einige ernsthafte Probleme habe, und ich bin wieder da, wo ich begann, 10 bis 12 Vergünstigungen pro Tag und 10 bis 12 norcos auch. sehr enttäuscht in mich, weil ic
  • Meine Tochter ist auf tri-cylen Geburt contronl und ist mit Übelkeit und Magenschmerzen, wie lange diese tun?

    ... letzte? ----schneiden---- In Antwort auf DzooBaby bei 2011-12-05 12.21 Normalerweise Nebenwirkungen absetzen nach dem ersten Monat nach unten, aber bei manchen Frauen können sie bis zu den ersten drei Zyklen bestehen. Wenn sie es nicht besser nac
  • Schizophrene ist das neue Verzögertes

    Schizophrene ist das neue Verzögertes
    Haben Schizophrenen multiple Persönlichkeiten haben? Etwas Seltsames geschieht mit dem Wort Schizophrenie, etwas , das es im Gegensatz zu jedem anderen Wort in der englischen Sprache macht. Es beginnt mit Metapher. Gelegentlich driften Worte aus der
  • CVS hat mir mg Aminocapronsäure 1000 wurde nicht mehr hergestellt?

    Mein Mann braucht es für eine Blutung / Blutkrankheit ... Ist es wahr, oder lügt CVS über dieses Medikament? ----schneiden---- In Antwort auf kaismama bei 2013.02.18 11.03 Ich habe kein Vertrauen jemals erfahren, was eine Apotheke sagt. Wenn ihr Vert
  • Die Wissenschaft der Anatomie befindet sich in einem Revival (Op-Ed)

    Die Wissenschaft der Anatomie befindet sich in einem Revival (Op-Ed)
    Ihre inneren Selbst. Credit: pureblacklove, CC BY-NC-SA Dieser Artikel wurde ursprünglich am veröffentlicht . Das Gespräch Die Veröffentlichung dazu beigetragen , den Artikel zu Live - Science Expert Stimmen: Op-Ed & Insights. Nur vor zwei Jahrzehnte
  • Stroke Prevention Tipps

    Stroke Prevention Tipps
    Hier sind sechs Schlaganfall-Prävention Tipps, die Ihnen helfen, verbessern Sie Ihre Chancen nie einen Schlaganfall zu erleiden. Obwohl Schlaganfall die dritthäufigste Todesursache in den Vereinigten Staaten ist, nur ein kleiner Prozentsatz der Ameri
  • Besorgt über in Diphenhydramin Pille verwendet Coloring: 44-329?

    Ich habe für Schlaflosigkeit Diphenhydramin genommen. Funktioniert gut die meiste Zeit. Meine Sorge ist die floressant-leuchtend orange Färbung auf der Außenseite der Pille verwendet. Ich weiß, das ist nicht eine sehr natürliche Farbe. Ich bin besorg
  • Wann werden Medikamente eigentlich ab?

    Wann werden Medikamente eigentlich ab?
    Wir haben alle wunderten sich über Medikamente nach dem Verfallsdaten verwenden. Ist es überhaupt sicher? Wie wichtig sind diese Daten? Und wie sollten wir abgelaufen Medikamente entsorgen? Was das Verfallsdatum Mittel Die meisten Medikamente haben e