Index · Artikel · Thailand wins praise for AIDS vaccine trial

Thailand wins praise for AIDS vaccine trial

2009-09-28 2
   
Advertisement
résuméHONG KONG/BANGKOK An experimental AIDS vaccine that appears to be the first to protect people was mired for years in controversy, and credit for its success must go to Thailand where the trial was conducted, experts said. The trial was criticised fiv
Advertisement

Thailand wins praise for AIDS vaccine trial


HONG KONG/BANGKOK An experimental AIDS vaccine that appears to be the first to protect people was mired for years in controversy, and credit for its success must go to Thailand where the trial was conducted, experts said.

The trial was criticised five years ago by 22 prominent U.S. scientists who doubted it would have any effect. Washington was accused of wasting more than a $100 million by funding it.

But Thai health authorities and their U.S. partners at the National Institutes of Health and the Walter Reed Army Institute of Research pressed on with the trial involving 16,000 volunteers in a country at the forefront of the battle against HIV.

"It was a tough decision. I am glad we made it," said Dr. Anthony Fauci, director of the U.S. National Institute of Allergy and Infectious Diseases, who defied the criticism and continued the trial.

The trial vaccine was made using two failed products -- Sanofi-Pasteur's ALVAC canary pox/HIV vaccine and AIDSVAX, made by a San Francisco company called VaxGen and now owned by the non-profit Global Solutions for Infectious Disease.

Donald Burke, dean of the University of Pittsburgh's Graduate School of Public Health, said the trial was controversial from the start and had been dismissed by prominent U.S. scientists because of the failure of previous vaccine tests.

"But given the importance of the AIDS epidemic, the decision was made to go forward regardless of these criticisms. It was a difficult choice, but a courageous choice," said Burke, who was head of AIDS research at Walter Reed before retiring in 1997.

Burke isolated the AIDS virus taken from a young HIV-infected Thai soldier in 1989 after Thai army doctors discovered an HIV outbreak among young recruits in Chiang Mai in northern Thailand. That virus sample went on to become one of the seed viruses in the experimental vaccine, Burke said.

"To their credit the Thais did a remarkable job on this," Dr. Eric Schoomaker, the Surgeon General of the U.S. Army, told reporters. "They did remarkable job of recruiting volunteers and conducting this trial almost flawlessly."

The $105 million trial was sponsored and paid for by the U.S. government and results showed it cut the risk of infection by 31.2 percent among 16,402 volunteers over three years.

THAI TRIUMPH

Those results mark a triumph for Thailand, a country of 67 million people where a booming sex industry had stoked fears of a major epidemic. Local authorities battled hard against a disease that threatened to spiral out of control some 20 years ago.

Experts had predicted that 4 million people would be infected by 2000 if nothing was done to slow the spread of HIV. But a massive government-led Aids education and prevention campaign in the early 1990s had an enormous effect.

HIV prevalence among injecting drug users in Thailand was as high as 30-50 percent in 1991, and 33.2 percent among female sex workers in 1994, according to UNAIDS. The number of infections has since been reduced to 20,000 annually from 140,000 in 1991.

Billboards and airwaves were bombarded with safe sex messages while health workers promoted condom use in the country's notorious sex trade. Leading the campaign was "Mr Condom," family planner-turned Public Health Minister, Meechai Viravaidya.

Health check-ups were made available to sex workers for free. Men were discouraged from visiting prostitutes and condom usage in Bangkok's brothels rose from 15 percent in the early 1990s to 98 percent by 2000.

Infection rates fell and the exercise remains widely cited as a model in disease prevention among health experts -- although numbers have shown signs of creeping up in the last few years among some high risk groups, such as gay and bisexual men.

Today, about 610,000 people in Thailand are now living with AIDS, according to UNAIDS.

"We are still strengthening a very strong platform," said Punnee Pitisuttithum, head of the HIV/AIDS research unit at Bangkok's Mahidol University, which has been involved in vaccine trials since 1994. "Before this trial, we had many disappointments but with this result, we see some light at the end of the tunnel."

(Additional reporting Maggie Fox in Washington; Editing by Jason Szep)

TOP

  • Day/
  • Week/
  • Original/
  • Recommand

Updated

  • Can you become addicted to tanning beds?

    Can you become addicted to tanning beds?
    NEW YORK (Reuters Health) - If you're someone who lies in a tanning bed too much, you may be likely to suffer from addictive behavior often seen with substance abuse, as well as anxiety, according to a new study. Catherine Mosher and Sharon Danoff-Bu
  • Ich bin Typ-1-Diabetiker mit einer sehr hohen A1C-Spiegel nehmen Lantus und humolog Insulin mein dr. hat hinzugefügt?

    ... Victoza für Diabetiker Typ 1 nur auf Typ2 keine Informationen zu finden, sollte ich diese nehmen ----schneiden---- In Antwort auf die Marvell bei 2011-02-17 06.26 Leider sind Sie, wenn Sie Typ1-Diabetes Insulin nicht selbst zu machen. So wird Vic
  • Wie lange dauert es von Trazodon zurückzuziehen?

    In diesen letzten 6 Wochen begann er einige Nebenwirkungen erfahren, dass er vorher nicht hatte. Er kämpft Übelkeit einen guten Teil des Tages, zusammen mit Müdigkeit und Schwindel, und seine Leber ist sichtlich geschwollen. Vor einer Woche reduziert
  • Morbus Behçet - Remicade - Enthält diese med Haarfarbe Änderungen verursachen?

    Ich habe bisher zwei Infusionen erhalten, da dies immer noch die Induktionsphase betrachtet wird. Ich habe bemerkt, dass meine Haarfarbe etwas dunkler geworden ist. Ist das üblich? ----schneiden---- In der Antwort auf Lady of ... bei 2011-05-27 18.40
  • Cleveland Clinic ernennt Führungsteam für die regionale Krankenhäuser

    Cleveland Clinic ernennt Führungsteam für die regionale Krankenhäuser
    Cleveland Clinic hat eine neue Führungsteam für seine neun Nordostohio regionalen Krankenhäusern. Die Führungskräfte im Team wird mit Fahr Qualität und Effizienz geladen werden, während die Sicherheit der Patienten zu verbessern, entsprechend einer A
  • Wie die Leonid Meteor zu beobachten Dieses Wochenende Dusche

    Wie die Leonid Meteor zu beobachten Dieses Wochenende Dusche
    Heute Abend-Freitag. Nov. 16- die Dusche Leonid Meteor auf ihrem Höhepunkt sein wird, mit 20 bis 30 oder so Sterne sichtbar pro Stunde zu schießen. Wenn Sie jemals außerhalb gewünscht haben zu sitzen und ein Meteorschauer, in den nächsten paar Nächte
  • Suffer Russlands Little Children?

    Suffer Russlands Little Children?
    Russische Anhänger der Opposition Kundgebung in Moskau gegen einen Kreml Gesetz zum Verbot US Adoptionen russischer Waisen. Tausende Menschen protestierten Russlands jüngste Verbot der amerikanischen Adoptionen russischer Kinder in Moskau über das Wo
  • Visuelle Verarbeitungs- und Wahrnehmungsstörungen

    Visuelle Verarbeitungs- und Wahrnehmungsstörungen
    Eine visuelle Verarbeitungsstörung bezieht sich auf eine verminderte Fähigkeit, bei der Verarbeitung von Informationen, die durch die Augen kommt. Eine Person mit einer visuellen Verarbeitung Störung hat Schwierigkeiten mit visuellen Input von einige
  • For One-Night-Stands, Gurtangelegenheiten

    For One-Night-Stands, Gurtangelegenheiten
    In einer neuen Studie über Penis Vorlieben, Frauen betrachtet und behandelt Penisse auf einem 3D-Drucker hergestellt. Die Modelle waren blau und kam in 33 verschiedenen Größen. Credit: Rachael Rettner für Live - Wissenschaft Für eine Nacht steht, Grö
  • Schaukelpferd Depot Rückrufe Schaukelpferd Spielzeug

    Schaukelpferd Depot Rückrufe Schaukelpferd Spielzeug
    Große Schaukelpferd. Credit: CPSC. Die US Consumer Product Safety Commission, in Zusammenarbeit mit Schaukelpferd Depot, von Buckeye, Ariz., Kündigte einen freiwilligen Rückruf von etwa 1200 Schaukelpferde heute. Gefahr: Die Zügel auf dem Schaukelpfe