Index · Artikel · Stem cells used to make pancreas, gut cells

Stem cells used to make pancreas, gut cells

2010-12-13 6
   
Advertisement
résuméWASHINGTON Stem cells can be transformed into the pancreatic cells needed to treat diabetes and into complex layers of intestinal tissue, scientists demonstrated in two experiments reported on Sunday. In one, a team turned immature sperm cells into p
Advertisement

Stem cells used to make pancreas, gut cells


WASHINGTON Stem cells can be transformed into the pancreatic cells needed to treat diabetes and into complex layers of intestinal tissue, scientists demonstrated in two experiments reported on Sunday.

In one, a team turned immature sperm cells into pancreatic tissue, while another team turned embryonic stem cells into complex layers of intestinal tissue.

Both studies show new ways to use stem cells, which are the body's master cells and which can come from a variety of sources.

A team at Georgetown University in Washington worked with spermatogonial stem cells, master cells that give rise to sperm in men.

Ian Gallicano and colleagues used germ-derived pluripotent stem cells, which are made from the spermatogonial stem cells. They nurtured these cells in the lab with compounds designed to make these cells start acting like pancreatic beta cells, which produce insulin.

When transplanted into diabetic mice, these cells produced insulin, acting like the pancreatic beta cells that the body mistakenly destroys in type-1 diabetes, Gallicano's team told a meeting of the American Society for Cell Biology in Philadelphia.

Currently, children and young adults diagnosed with type-1 diabetes must take insulin for life.

A few may be treated with the so-called Edmonton Protocol, in which the missing pancreatic cells are transplanted from cadavers. But there is a shortage of these cells and the patients may suffer from graft-versus-host disease if the cells are not a good match.

Gallicano said men's own cells could be used as a source of their transplants, and he said perhaps the approach may work in women too. "While these cells come from the human testis, the work here is not necessarily male-centric," they wrote. "These fundamental aspects could easily be applied to the female counterpart, oocytes."

Separately, James Wells and colleagues at Cincinnati Children's Hospital Medical Center in Ohio turned two different kinds of stem cell into complex layers of intestinal tissue.

They used both human embryonic stem cells -- taken from days-old embryos -- and induced pluripotent stem cells -- made from ordinary cells transformed by introducing certain genes.

Both types have the power to give rise to all the cell and tissue types in the body when cultured in the lab like the Georgetown team did.

Writing in the journal Nature, Wells's team showed they could transform these cells into what they called organoids -- batches of intestinal tissue made out of the layers of the various cells that make up intestine, including muscle cells and the cells that line the inside of the gut and that produce several vital compounds.

These organoids can be used to study intestinal diseases such as necrotizing enterocolitis, inflammatory bowel diseases and short-gut syndromes and perhaps could be used to treat them someday, Wells's team said.

(Editing by Eric Walsh)

  • Stem cells used to make pancreas, gut cells

    Stem cells used to make pancreas, gut cells
    WASHINGTON Stem cells can be transformed into the pancreatic cells needed to treat diabetes and into complex layers of intestinal tissue, scientists demonstrated in two experiments reported on Sunday. In one, a team turned immature sperm cells into p
    2010-12-13 STEMCELLS
  • Banking stem cells could save Japan nuclear workers

    Banking stem cells could save Japan nuclear workers
    CHICAGO Health officials should collect blood from workers at the crippled Fukushima Daiichi nuclear power plant in case they are accidentally exposed to high levels of radiation and need a stem cell transplant, Japanese researchers said on Thursday.
    2011-04-15 STEMCELLSJAPAN
  • Stem cells "seek and destroy" cancer cells: study

    Stem cells "seek and destroy" cancer cells: study
    CHICAGO Genetically engineered stem cells from bone marrow showed promise as a potential new way to deliver a cancer-killing protein to tumors, British researchers said on Tuesday. Experiments in cell cultures and in mice showed the adult stem cells
    2009-05-19 CANCERTREATMENT
  • U.S. company finds "safer" way to make stem-like cells

    U.S. company finds "safer" way to make stem-like cells
    WASHINGTON U.S. researchers said on Thursday they had come up with the safest way yet to make stem-like cells using a patient's ordinary skin cells, this time by using pure human proteins. The team at Harvard University and Massachusetts-based Advanc
  • GE teams up with Geron for stem-cell research

    GE teams up with Geron for stem-cell research
    BOSTON General Electric Co is teaming up with U.S. biotech company Geron Corp to use stem cells to develop products that could give drug developers an early warning of whether new medicines are toxic. The venture is the largest U.S. conglomerate's mo
    2009-06-30 STEMCELLS
  • Researchers take another stem cell step

    Researchers take another stem cell step
    WASHINGTON Researchers trying to figure out a safe way to turn an ordinary skin cell into a powerful stem cell treatment said they took another big step on Thursday, using one chemical to partly transform the cells. Dr. Kevin Eggan of the Harvard Ste
    2009-10-09 STEMCELLS
  • Company seeks to test stem cells for blindness

    Company seeks to test stem cells for blindness
    WASHINGTON Advanced Cell Technology, a small Massachusetts-based biotechnology company, said on Thursday it has asked for approval to test human embryonic stem cells in treating a rare cause of blindness. The company said it filed an IND, an investig
    2009-11-19 STEMCELLSEYE
  • U.S. researchers make stem cells quickly from skin

    U.S. researchers make stem cells quickly from skin
    WASHINGTON Researchers have found a surprisingly quick and apparently safe way to transform ordinary skin cells into both stem cells -- the body's master cells -- and muscle cells. They said on Thursday their method may provide a way to generate tiss
    2010-09-30 STEMCELLSMETHOD
  • First patient treated in Geron stem cell trial

    First patient treated in Geron stem cell trial
    WASHINGTON U.S. doctors have begun treating the first patient to receive human embryonic stem cells, but details of the patient enrolled in the landmark clinical trial are being kept confidential, Geron Corp said on Monday. Geron, whose shares were u
    2010-10-11 STEMCELLSGERON
  • Stem cell trial offers hope for vision patients

    Stem cell trial offers hope for vision patients
    WASHINGTON Christopher Goodrich of Portland, Oregon, can't wait to stick a needle in his eye. Goodrich hopes to be one of the first patients enrolled in clinical trial that just got a go-ahead from the U.S. Food and Drug Administration, only the seco
  • South Korea sets sights on becoming stem cell powerhouse, again

    South Korea sets sights on becoming stem cell powerhouse, again
    SEOUL South Korea's president vowed on Monday a series of regulatory reforms to help regain its place as a stem cell research powerhouse, trying to reclaim momentum five years after a cloning scandal. President Lee Myung-bak said that by breathing ne
    2011-09-19 STEMCELLKOREA
  • Scientists use cloning to make human stem cells

    Scientists use cloning to make human stem cells
    CHICAGO U.S. scientists for the first time have used a cloning technique to get tailor-made embryonic stem cells to grow in unfertilized human egg cells, a landmark finding and a potential new flashpoint for opponents of stem cell research. The resea
    2011-10-05 STEMCELLSCLONING
  • Top-grade stem cells seen boosting research trials

    Top-grade stem cells seen boosting research trials
    LONDON British scientists have made the first human embryonic stem cells of a high enough grade to use in patients and deposited them in a public stem cell bank for development in human trials by drug companies and researchers by 2014. A team from Ki
    2011-12-06 STEMCELLSBRITAIN
  • First patients shown to improve with embryonic stem cells

    First patients shown to improve with embryonic stem cells
    NEW YORK Before treatment, the 51-year-old graphic artist was legally blind, unable to read a single letter on a standard eye chart. She has suffered from Stargardt's disease, the most common form of macular degeneration in young patients, since she
    2012-01-23 STEMCELLS
  • Top French court backs stem-cell research

    Top French court backs stem-cell research
    PARIS France's top court approved a law on Thursday making it easier to conduct research on human embryos and stem cells as long as strict rules are followed to prevent cloning. Predominantly Roman Catholic France has until now had tough curbs on emb
    2013-08-01 STEMCELLSFRANCE
  • In a cloning first, scientists create stem cells from adults

    In a cloning first, scientists create stem cells from adults
    NEW YORK Scientists have moved a step closer to the goal of creating stem cells perfectly matched to a patient's DNA in order to treat diseases, they announced on Thursday, creating patient-specific cell lines out of the skin cells of two adult men.
    2014-04-17 SCIENCECLONING
  • EU's top court opens door to some stem cell patents

    EU's top court opens door to some stem cell patents
    BRUSSELS/LONDON Europe's top court has opened the door to certain stem cell patents in the European Union by ruling that an organism incapable of developing into a human being is not a human embryo and may be patented. Thursday's judgment by the Euro
  • Scientists create liver cells from patients' skin

    Scientists create liver cells from patients' skin
    LONDON Scientists have created liver cells in a lab for the first time using reprogrammed cells from human skin, paving the way for the potential development of new treatments for liver diseases that kill thousands each year. Cambridge University sci
    2010-08-25 STEMCELLSLIVER
  • MRI, solar cells, aging work lead Nobel predictions

    MRI, solar cells, aging work lead Nobel predictions
    WASHINGTON Scientists who discovered the secrets of how cells age, who made efficient solar cells possible and who figured out how to watch the brain work in real time are all leading contenders for Nobel prizes, Thomson Reuters predicted on Thursday
    2009-09-24 NOBELSPREDICTION
  • Scientists say curry compound kills cancer cells

    Scientists say curry compound kills cancer cells
    LONDON A molecule found in a curry ingredient can kill esophageal cancer cells in the laboratory, suggesting it might be developed as an anti-cancer treatment, scientists said on Wednesday. Researchers at the Cork Cancer Research Center in Ireland tr
    2009-10-28 CANCERCURRY

TOP

  • Day/
  • Week/
  • Original/
  • Recommand

Updated