Index · Artikel · Researchers take step to 'universal' flu vaccine

Researchers take step to 'universal' flu vaccine

2010-05-25 3
   
Advertisement
résuméWASHINGTON A "headless" version of the influenza virus protected mice from several different strains of flu and may offer a step toward a so-called universal flu vaccine, researchers reported on Tuesday. They identified a piece of the virus that
Advertisement

Researchers take step to 'universal' flu vaccine


WASHINGTON A "headless" version of the influenza virus protected mice from several different strains of flu and may offer a step toward a so-called universal flu vaccine, researchers reported on Tuesday.

They identified a piece of the virus that appears to be the same even among mutated strains, and found a way to make it into a vaccine.

Years of work lie ahead but if it works in people the way it worked in mice, the new vaccine might transform the way people are now immunized against influenza, the team at the Mount Sinai School of Medicine in New York reported.

"We now report progress toward the goal of an influenza virus vaccine which would protect against multiple strains," Dr. Peter Palese, Dr. Adolfo Garcia-Sastre and colleagues report in a new journal mBio, available here

"Current influenza vaccines are effective against only a narrow range of influenza virus strains. It is for this reason that new vaccines must be generated and administered each year."

Flu viruses mutate constantly and each year a cocktail of three flu vaccines is tweaked to try and hit the most common new mutations. Every few decades a new pandemic strain emerges -- a year ago the new H1N1 swine flu strain started a pandemic and it has been added to the seasonal flu vaccine mix.

It takes months to make a new flu vaccine and governments and commercial drug companies struggled to get the new H1N1 vaccine out by last September. Having a universal flu vaccine could, in theory, prevent future pandemics and keep seasonal flu under better control.

VULNERABLE NECK

Palese's team focused on an important piece of the flu virus called hemagglutinin. This mushroom-shaped structure helps the virus attach to the cells it infects and gives flu viruses the "H" in their names.

The "neck" of hemagglutinin does not mutate the way more visible bits of the virus do, and if there was an easy way to help the immune system to see it, this provides a good antigen -- a target for a vaccine.

But the top, umbrella-shaped part of the hemagglutinin protein hides this vulnerable neck from the immune system. Palese's team found a way to get to the neck, cut it out and make a vaccine out of it

"A headless hemagglutinin molecule could form the basis for a broadly protective influenza virus vaccine," the researchers wrote.

"This paper is more proof of concept," Garcia-Sastre said in a telephone interview. "We don't think we have yet the most optimal way to display the antigen."

Tests in mice showed the vaccine protected them from otherwise lethal doses of multiple strains of influenza.

Garcia-Sastre's team made a plasmid, a circular piece of DNA, for their vaccine but other ways to do it include a virus-like particle, used in other vaccines, or bits of DNA made by a baculovirus, he said. He said they are open to working with a drug company on this.

Flu infects up to 10 to 15 percent of the U.S. population each year, more in a pandemic year, and kills an estimated 36,000.

Dozens of companies make influenza vaccines and bring in millions of dollars in revenues from them. The United States, for instance, bought 162 million doses of H1N1 vaccine from five makers -- Novartis, AstraZeneca unit MedImmune, Sanofi Aventis, GlaxoSmithKline and Australian vaccine maker CSL.

(Editing by Eric Walsh)

  • Researchers take step to 'universal' flu vaccine

    Researchers take step to 'universal' flu vaccine
    WASHINGTON A "headless" version of the influenza virus protected mice from several different strains of flu and may offer a step toward a so-called universal flu vaccine, researchers reported on Tuesday. They identified a piece of the virus that
    2010-05-25 FLUVACCINE
  • Two-step vaccine may offer "universal" flu jab

    Two-step vaccine may offer "universal" flu jab
    WASHINGTON A two-step flu vaccine using DNA to "prime" the immune system and then a traditional seasonal influenza vaccine may be able to protect against all strains of the virus -- providing a long-sought "universal" flu vaccine, U.S.
    2010-07-16 FLUVACCINE
  • Insight: U.S. government investment gives flu vaccines a shot in the arm

    Insight: U.S. government investment gives flu vaccines a shot in the arm
    CHICAGO Fighting the flu may soon get easier. As early as next year, more modern and more effective vaccines will hit the market, thanks to investments by the U.S. government and pharmaceutical companies. And even bigger scientific advances are expec
    2013-01-19 FLUVACCINES
  • In U.S., flu vaccine worked in just over half of those who got it

    In U.S., flu vaccine worked in just over half of those who got it
    CHICAGO A U.S. government analysis of this season's flu vaccine suggests it was effective in only 56 percent of people who got the shot, and it largely failed to protect the elderly against an especially deadly strain circulating during flu season. T
    2013-02-21 FLUVACCINEUSA
  • Everyone in U.S. should get flu vaccine: experts

    Everyone in U.S. should get flu vaccine: experts
    WASHINGTON Everyone in the United States over the age of six months should get seasonal influenza vaccines every year, federal vaccine advisers said on Wednesday. The Advisory Committee on Immunization Practices made the long-awaited vote to recommen
    2010-02-25 FLUUSA
  • Regular flu vaccine little help against new strain

    Regular flu vaccine little help against new strain
    WASHINGTON The seasonal flu vaccine provides virtually no protection against the new H1N1 influenza strain, federal health researchers confirmed on Thursday. Their study using stored blood samples supports an intriguing theory that people over the ag
    2009-05-22 FLUIMMUNITY
  • Many health workers won't take swine flu vaccine

    Many health workers won't take swine flu vaccine
    NEW YORK (Reuters Health) - Even though testing has so far raised no "red flags" regarding safety of potential swine flu vaccines, surveys and focus groups show that healthcare workers and members of the public may be leery of being getting shot
    2009-08-27 FLUVACCINE
  • World needs to update its flu vaccines: study

    World needs to update its flu vaccines: study
    n">As Americans line up for flu shots, they should consider that the vaccines may be far less effective than thought, according to a new study. Michael Osterholm, an infectious disease specialist at the University of Minnesota, and his colleagues
    2011-10-25 FLUVACCINESLANCET
  • CSL starts U.S. swine flu vaccine trial

    CSL starts U.S. swine flu vaccine trial
    WASHINGTON CSL Ltd started testing its swine flu vaccine on U.S. children and adults on Monday, joining other companies testing the H1N1 vaccine as they also step up production. The Australian-based company said it would test 1,300 adults and 450 chi
    2009-08-24 FLUVACCINECSL
  • People will fear flu vaccine "adverse events": study

    People will fear flu vaccine "adverse events": study
    WASHINGTON Fear of adverse events such as miscarriages, rare neurological conditions and ordinary heart attacks will discourage some people from participating in mass vaccination efforts to fight swine flu, but public health experts said on Friday th
    2009-10-30 FLUVACCINEEVENTS
  • Medical workers balk at mandatory flu vaccines

    Medical workers balk at mandatory flu vaccines
    LOS ANGELES Even as they are forced to wait like everyone else for swine flu vaccines in short supply, thousands of nurses and other front-line healthcare workers are fighting mandatory flu immunization policies being put in place by some U.S. hospit
    2009-11-13 FLUNURSES
  • Giving flu vaccine to tots cuts ER visits

    Giving flu vaccine to tots cuts ER visits
    n">Recommending that all U.S. preschoolers get a flu shot cut visits to the emergency department for flu-like illness by more than a third, U.S. and Canadian researchers said on Monday in a study that showed the direct impact of vaccination policy
    2011-09-19 FLUCHILDRENUSA
  • All UK kids to get AstraZeneca's nasal flu vaccine

    All UK kids to get AstraZeneca's nasal flu vaccine
    LONDON Britain is to extend its seasonal flu vaccination program to all children, free of charge, becoming the first country in the world to do so, the Department of Health said on Wednesday. Children will get AstraZeneca's nasal spray vaccine rather
    2012-07-25 FLUAstrazeneca
  • Italy bans Novartis flu vaccines pending tests

    Italy bans Novartis flu vaccines pending tests
    ROME/ZURICH Italy banned the sale and use of anti-influenza vaccines produced by Novartis on Wednesday pending tests for possible side effects, prompting authorities in Switzerland to also take precautionary steps. The Italian Health Ministry advised
    2012-10-24 NOVARTISITALY
  • Novartis defends flu vaccines after Italian ban

    Novartis defends flu vaccines after Italian ban
    ZURICH Swiss drugmaker Novartis said flu vaccines that Italy has banned from sale are safe and it does not expect other countries to take similar action. Italy banned four anti-influenza vaccines produced by Novartis on Wednesday pending tests for po
    2012-10-25 VACCINESNOVARTIS
  • Flu vaccine not linked to fetal death

    Flu vaccine not linked to fetal death
    NEW YORK (Reuters Health) - Getting the flu vaccine while pregnant does not increase the odds that the fetus will die in the womb, according to a new study of tens of thousands of women in Norway. Although fetal deaths were rare during the study, the
    2013-01-16 FLUVACCINE
  • FDA cites GSK flu vaccine plant for quality violations

    FDA cites GSK flu vaccine plant for quality violations
    WASHINGTON A GlaxoSmithKline Plc plant in Canada that makes the flu vaccine Flulaval has been cited by the U.S. Food and Drug Administration for failing to meet quality control standards. GSK said it is working to rectify the problems and does not ex
    2014-06-24 FDAGSKWARNING
  • CDC says it is too late to make new flu vaccine for this season

    CDC says it is too late to make new flu vaccine for this season
    n">The U.S. Centers for Disease Control and Prevention said on Thursday it is too late to make new flu vaccines for the current flu season that could better protect against the predominant flu virus now circulating in the United States. On Wednesd
    2014-12-04 FLUCDCUSA
  • U.S. directs $1 billion for new swine flu vaccine

    U.S. directs $1 billion for new swine flu vaccine
    WASHINGTON The U.S. government said on Friday it is setting aside $1 billion to help companies develop a vaccine against the new strain of H1N1 influenza that is sweeping the world. U.S. Health and Human Services (HHS) Secretary Kathleen Sebelius sai
    2009-05-22 FLUVACCINEUSA
  • U.S. plans for autumn swine flu vaccination campaign

    U.S. plans for autumn swine flu vaccination campaign
    WASHINGTON The United States is planning for a vaccination campaign against the new H1N1 flu that could move into schools and community centers, Health and Human Services Secretary Kathleen Sebelius said on Thursday. Sebelius led off a "summit"
    2009-07-09 FLUUSASEBELIUS

TOP

  • Day/
  • Week/
  • Original/
  • Recommand

Updated

  • Cefepime in Patienten mit Neutropenie eingesetzt?

    Aml Patient war auf Vancomycin geschaltet cefepime, was der Grund für den Schalter wäre, zusätzlich war auf einem zweiten Breitbandantibiotikum, zestrin ----schneiden---- In Antwort auf 2009.11.15 01.52 bis suzanne66 Sie haben die Person zu fragen, w
  • Kann Vivelle (dot) Ursache Ausschlag + Juckreiz an den Füßen und Knöcheln?

    Dies scheint zu stoppen, wenn ich den Patch zu stoppen und starten Sie wieder etwa 8 Stunden, nachdem ich neu starten. ----schneiden---- In Antwort auf 2010.06.15 01.01 Uhr bis r.leslee NACH Lippincotts Pflegedrogen Guide, Vivelle können verschiedene
  • Fish oil may curb depression among teen boys

    Fish oil may curb depression among teen boys
    NEW YORK (Reuters Health) - Eating more oily fish like sardines, salmon and yellowtail could help teenage boys feel less blue, suggests a new Japanese study. The same does not appear to hold for teen girls, however. Omega-3 fatty acids, including EPA
  • Cameron seeks to end "sick-note" culture

    Cameron seeks to end "sick-note" culture
    LONDON Britain is to examine why so many people end up on long-term sick leave, fuelling a 192 billion pound annual bill for welfare, Prime Minister David Cameron announced on Thursday. The government is already preparing to reassess the circumstance
  • Wie für ein Vorstellungsgespräch vorbereiten, wenn Sie nicht von Natur aus Outgoing sind

    Wie für ein Vorstellungsgespräch vorbereiten, wenn Sie nicht von Natur aus Outgoing sind
    Per Definition ist der Begriff abgehenden Mittel in sozialen Einstellungen zuversichtlich. Für die meisten Menschen, die schüchtern oder sozial ungeschickt sind, ist es leicht bei dem Gedanken an einem sozialen Umfeld überwältigt zu werden. Vielleich
  • Verwenden Sie Guided Imagery Für Entspannung

    Verwenden Sie Guided Imagery Für Entspannung
    Guided Imagery ist eine bequeme und einfache Entspannungstechnik, die Sie schnell helfen können und leicht verwalten Stress und Verspannungen im Körper zu reduzieren. Itâ € ™ praktisch so einfach ist, als in einem lebendigen daydream frönen und mit d
  • 5 Wege, um die Wahrscheinlichkeit eines Kaiserschnitt zu senken

    5 Wege, um die Wahrscheinlichkeit eines Kaiserschnitt zu senken
    Sectiones - chirurgische Geburten - sind nicht immer vermeidbar. Und manchmal sind sie buchstäblich Leben retten. In den meisten Fällen kann jedoch C-Bereiche vermieden werden - und das ist eine gute Sache. Es gibt eine Vielzahl von Vorteilen für die
  • Patella Tendonitis - Jumper Knie

    Patella Tendonitis - Jumper Knie
    Die Patellarsehne verbindet die Kniescheibe (Patella) mit dem Schienbein. Dies ist Teil des 'Extensormechanismus' des Knies, und zusammen mit der Kniescheibe, Quadrizepssehne und der Quadrizeps, diese Strukturen lassen Sie Ihre Knie zu strecken, und
  • Medizinisches Gerät / Life-Science-Start-ups, die den nächsten 36 Monaten "wird im catbird Sitz" überleben

    Medizinisches Gerät / Life-Science-Start-ups, die den nächsten 36 Monaten "wird im catbird Sitz" überleben
    Eine Umfrage von 31 San Francisco Venture-Kapitalisten die Aussichten für die nächsten sechs bis 18 Monaten hat das Vertrauen leicht nach oben im dritten Quartal des Jahres, aber nicht für Life Science und Healthcare-Investitionen zu finden, wo die L
  • Obesity Gerätehersteller zieht $ 5.5M für Studien des Magens in 'Weste' Implantat

    Obesity Gerätehersteller zieht $ 5.5M für Studien des Magens in 'Weste' Implantat
    A California Unternehmen für medizinische Geräte, eine weniger invasive Alternative zur Chirurgie auf den Markt zu bringen, der Hoffnung, sagt itâ € ™ s $ 5.500.000 von Investoren eingeworben, um das Gerät beim Menschen zu testen. Onciomed entwickelt