In U.S., flu vaccine worked in just over half of those who got it
CHICAGO A U.S. government analysis of this season's flu vaccine suggests it was effective in only 56 percent of people who got the shot, and it largely failed to protect the elderly against an especially deadly strain circulating during flu season.
The U.S. Centers for Disease Control and Prevention said the findings underscore the need for more effective weapons in the fight against influenza, which kills between 3,000 and 50,000 people in the United States each year depending on the severity of the flu season.
"We simply need a better vaccine against influenza, one that works better and lasts longer," CDC Director Dr. Thomas Frieden said in a statement on Thursday.
Experts generally estimate the effectiveness of flu vaccines to be between 50 percent and 70 percent, but this vaccine appears to have fallen on the low side of that range.
The vaccine did cut the risk of medical visits caused by either influenza A or influenza B by 56 percent, according to the study published in the CDC's Morbidity and Mortality Weekly Report.
It was more effective against influenza B, protecting 67 percent of those who were vaccinated. Against the influenza A (H3N2) strain, the vaccine protected only 47 percent.
The protective benefits of the vaccine against influenza B were consistent across age groups. That was not the case with the influenza A (H3N2) component of the vaccine, which protected 46 percent to 58 percent of people aged 6 months to 64 years, but only 9 percent of those 65 and older, a finding that was statistically insignificant.
The estimates are based on studies of 2,697 children and adults enrolled in the U.S. Influenza Vaccine Effectiveness Network between December 3 and January 19. The CDC said those estimates may change by the end of the flu season, when more people have been sampled.
Even so, the findings suggest that a large group of elderly people, who are consistently the most vulnerable to influenza, were unprotected during this year's flu season.
POOR IMMUNE RESPONSE TO VACCINES
One possible explanation may be that in older individuals, the immune system often produces a less robust immune response to vaccines, or to any infection.
CDC experts suggested that poor immune response to the influenza A (H3N2) component of the vaccine may help explain why the elderly were not protected, but said in the report the findings "should not discourage future vaccination by persons aged 65 years (or older), who are at greater risk for more severe cases and complications from influenza."
Dr. Joseph Bresee, a flu expert at the CDC, said overall the vaccine worked "OK," but it is not fully clear why people over 65 responded poorly.
"Part of it is they are elderly and they respond less vigorously to vaccines. But it appears that some of the people, at least, developed a less robust response to this particular antigen," he said, referring to the H3N2 component of the flu vaccine.
"Why that is, I don't think we know yet. We're looking at it closely," he said.
Bresee said most of the elderly in the study took conventional flu vaccine, and not the high-dose version developed by vaccine giant Sanofi to address issues of poor immune responses in the elderly.
"We'd love to be able to look at the question of whether it is actually more effective or not. We just don't have enough use yet," he said.
Sanofi said it shipped 6 million doses of the special formulation for the elderly, but it did not have information on how many of the doses were used, or whether any had been used by patients in the study.
What is clear, Bresee said, is the need for the elderly who get sick with flu symptoms to seek treatment with antiviral medications, such as Roche Holding Ag's Tamiflu, which can reduce the severity of their illness.
CDC noted that vaccine effectiveness has been known to vary based on a number of factors including virus type, age, the particular flu season and variations in an individual's immunity.
"Although it's far from perfect, flu vaccination is by far the best tool we have to protect from flu," Frieden said.
Frieden said the U.S. Department of Health and Human Services as well as pharmaceutical companies are working to produce better vaccines. Efforts include the use of genetic engineering to develop more potent and more modern flu vaccines, with the hope of ultimately developing a universal flu vaccine that could protect against all strains of flu. Experts predict that could be possible within eight to 10 years.
"It's going to be hard but it's well worth the effort," Frieden said.
Already there are signs of change. In November, the Swiss drugmaker Novartis won U.S. Food and Drug Administration approval for Flucelvax, a seasonal flu vaccine grown in animal cell cultures instead of live chicken eggs, a speedier and more reliable process that could help build stockpiles in the event of a pandemic.
In December, GlaxoSmithKline won FDA approval for a new seasonal flu shot called Fluarix that protects against four strains of seasonal flu - known as a quadrivalent vaccine - instead of three strains, known as a trivalent vaccine. The announcement followed the approval last February of AstraZeneca's four-strain flu nasal spray made by the company's MedImmune unit. Current vaccines tackled two A strains and one B strain. The quadrivalent vaccines will add an additional B strain.
Last month, the FDA approved the first gene-based flu vaccine developed by privately held Protein Sciences Corp, which uses genetic engineering to grow portions of the virus in insect cells.
"What we're looking at is really incremental improvements, because if we could make the breakthrough improvements easily it would have happened already," Dr. Leonard Friedland, vice president of clinical and medical affairs for vaccines in North America at GlaxoSmithKline, said in an interview last month.
Glaxo's Fluarix is the first inactivated flu shot to include four instead of three strains of flu.
"It was just licensed and will be available for next season," Friedland said, noting that Sanofi is also in the process of having their four-strain flu vaccine approved.
AstraZeneca's FluMist, a live, attenuated or weakened flu vaccine, will also have a four-strain version available for next flu season.
Dr. Chris Ambrose, a vice president at AstraZeneca's MedImmune unit, said the company plans to completely switch to the four-strain version of Flumist.
Sanofi Spokeswoman Donna Cary said the company has produced flu vaccines for specific age groups, including its high dose vaccine for the elderly.
"The next step for the future is to get to the point where we don't need to develop a new vaccine every year," Cary said. "The main thing we are all looking forward to is the universal vaccine."
(Additional reporting by Bill Berkrot in New York; Editing by Mohammad Zargham)
WASHINGTON The seasonal flu vaccine provides virtually no protection against the new H1N1 influenza strain, federal health researchers confirmed on Thursday. Their study using stored blood samples supports an intriguing theory that people over the ag
WASHINGTON The U.S. government said on Friday it is setting aside $1 billion to help companies develop a vaccine against the new strain of H1N1 influenza that is sweeping the world. U.S. Health and Human Services (HHS) Secretary Kathleen Sebelius sai
WASHINGTON The United States is planning for a vaccination campaign against the new H1N1 flu that could move into schools and community centers, Health and Human Services Secretary Kathleen Sebelius said on Thursday. Sebelius led off a "summit"
WASHINGTON The Food and Drug Administration approved the ordinary seasonal flu vaccine on Monday and said Americans should plan to be vaccinated. Vaccines against seasonal flu usually become available in September or October and flu experts say it is
GAITHERSBURG, Maryland The U.S. Food and Drug Administration wants to help rush through approval of new vaccine to fight the pandemic H1N1 virus, promising to watch more closely than ever bad effects from the immunization, officials said on Thursday.
WASHINGTON Vaccine experts who advise the U.S. government are likely on Wednesday to put healthcare workers, pregnant women and patients with asthma and diabetes at the front of the line to get vaccinated against the new pandemic H1N1 influenza. The
LONDON/PARIS Novartis has started human testing of H1N1 swine flu vaccine candidates while Sanofi-Aventis, the world leader in flu shots, will commence within days, company officials said on Tuesday. The launch of clinical trials is a key part of a w
WASHINGTON CSL Ltd started testing its swine flu vaccine on U.S. children and adults on Monday, joining other companies testing the H1N1 vaccine as they also step up production. The Australian-based company said it would test 1,300 adults and 450 chi
NEW YORK (Reuters Health) - Even though testing has so far raised no "red flags" regarding safety of potential swine flu vaccines, surveys and focus groups show that healthcare workers and members of the public may be leery of being getting shot
WASHINGTON U.S. health officials said on Thursday more than 6 million doses of H1N1 swine flu vaccine will be available the first week of October, twice as many as they expected only a week ago. But even as officials ramp up vaccine production, they
LONDON European healthcare regulators recommended two swine flu vaccines for approval on Friday, clearing the way for mass vaccination programs to start imminently. Governments and manufacturers have been scrambling for vaccines to target the new H1N
CHICAGO A top U.S. health official says the first weeks of October are going to be "a little bumpy" as the government distributes the supply the swine flu vaccine ready next week -- knowing it will not be enough. Dr. Thomas Frieden, director of
BRUSSELS The European Commission said on Tuesday it has authorized two H1N1 swine flu vaccines for use in the European Economic Area this year, paving the way for mass vaccinations before the start of the flu season. Governments and drugmakers have b2009-09-29 VACCINES
PERTH Australia rolled out a nationwide vaccination drive for H1N1 influenza on Wednesday in a bid to arm itself against a possible outbreak of the disease. Health Minister Nicola Roxon said 5.5 million doses of the vaccine have been delivered across
WASHINGTON The very first doses of swine flu vaccine will start arriving in states and cities that ordered it on Tuesday, and might be sprayed up the first patients' noses by the end of the week, U.S. health officials said on Thursday. Dr. Anne Schuc
WASHINGTON Healthcare workers in Indiana and Tennessee will be among the first to get swine flu vaccines in the United States on Monday, the U.S. Centers for Disease Control and Prevention said. Vaccination clinics are scheduled for Monday morning fo
WASHINGTON Delivery of some swine flu vaccines has been delayed because companies cannot make it as fast as they had hoped, just as the virus has really started to spread, the U.S. Centers for Disease Control and Prevention said on Friday. The CDC's
GENEVA Only one dose of vaccine is needed for protection against pandemic H1N1 flu and the jabs have so far proved to be safe, the World Health Organization said on Friday. Health experts have been debating whether one or two shots are necessary to p
WASHINGTON A quarrel between the U.S. government and swine flu vaccine makers reached the highest level on Friday, with President Barack Obama expressing frustration at the slow pace of production. Federal officials have slashed their initial estimat
WASHINGTON Fear of adverse events such as miscarriages, rare neurological conditions and ordinary heart attacks will discourage some people from participating in mass vaccination efforts to fight swine flu, but public health experts said on Friday th
- 06-291Kekse, Käse, und ein Panda auf der Fancy Food Show
- 01-172Ist Acomplia ein Makrolid?
- 10-223Cleveland Clinic Hotel bekommt "gut" (Wochenend-Runden)
- 11-184Chelseas Northera für Parkinson-Patienten erhält FDA Priority Review
- 01-105One in six adults goes on drinking binges: CDC
- 02-01611 Minuten zu einer friedlichen Mealtime
- 03-127Live Like Lizenz: Die vielen gesundheitlichen Vorteile von Hunde, Bester Freund des Mannes
- 03-288Zykloplegische Augentropfen
- 03-319Die Bedeutung der NEAT-Aktivität für Ihre Gesundheit
- 08-251Welche Clarithromycin Produkte sind in Indien zur Verfügung?
- 05-052Hat Vinblastin keine neurologischen Symptome bei Hunden wie die Unfähigkeit, zu gehen?
- 12-233I Have Bipolar Mixed Manic Depressive. Ist es unerhört ohne Schlafprobleme diagnostiziert werden?
- 01-184Was bedeutet die generische Marke von alprazlam aussehen?
- 12-095Effexor XR - Hat jemand auf Effexor haben Schwierigkeiten, Gewicht zu verlieren?
- 02-116Was ist Mixed-Persönlichkeitsstörung?
- 10-30710 Tipps zur Vermeidung von Infektionen
- 07-228Wie viel ZENPEP sollte eine 64 Jahre alte weiße Frau mit einem Gewicht von 160 Pfund pro Mahlzeit nehmen?
- 04-099Ist es eine gute Idee zu verdunsten und Inhale Alkohol?
- Soy may lessen risk of endometrial, ovarian cancers
- Mein Arzt erhöhte vor kurzem meine Rohwasser von Januvia 25 mg bis 50 mg. Ich schüttle jetzt wie aleaf?
- Mein Arzt hat mir 10 mg Prozac verschrieben. Aber ich nahm einen ruhig schlafen, pflanzliches Präparat, das?
- Wie man Ruine ein gesundes Frühstück
- Aus Gründen der Ihre Nachkommen essen, eine gesunde Ernährung
- Täglich Störungen Rhythmus Verbunden mit Fruchtbarkeitsstörungen
- Australiens Außerordentliche politische Drama über Klimawandel
- Die Don'ts der Potty Training
- Low Back Flexion Übung
- Knie-Arthrose-Behandlungen - Welche am besten funktioniert?
- Jentadueto vs. Metformin allein?
- Denkbare Miracle oder Fruchtbarkeit Betrug? Wie ein Scam Spot
- Viibryd - erleben Jeder Zorn?
- (A Real) Space Oddity
- Krankenversicherung Albtraum - Wo ist katastrophal Versicherung?
- Wie erhalte ich in Laufen Kinder interessieren
- Contest crowdsources Ideen Krankenhäuser schneiden tödlichen nosokomialen Infektionen zu helfen
- Kann ich HIV von Kissing bekommen?
- WASHINGTON A wart virus best known for causing cervical cancer may make for a less-deadly kind of head and neck cancer, researchers reported on Thursday. People whose head and neck tumors carried the human papillomavirus virus, or HPV, were 59 percen
- SAN FRANCISCO A multistate outbreak of antibiotic-resistant Salmonella believed to be linked to eating contaminated ground turkey has sickened 77 people and resulted in one known death, U.S. health authorities said. Some 26 states reported the illnes
- Im Mai 2010 wurde Minnesota als einer der ersten Staaten in der Nation für den Austausch von elektronischen klinischen Gesundheitsakte Informationen zwischen Gesundheitsdienstleistern, Einrichtungen und anderen Einrichtungen wie Apotheken und Labors
- Ich habe ein Rezept von Singulair, die 3 Monate alt ist, und ich weiß nicht, ob ich es meinem Kind verzichten sollte. Können Sie mir helfen, diese Frage beantworten? ----schneiden---- In Antwort auf die Marvell bei 2011-12-30 04.29 Meinen Sie, Sie da
- Dank der öffentlichen Gesundheit Ankündigungen und Bildung in der Sonne Sicherheit, wissen die meisten Menschen jetzt über die Gefahren von Sonnenbaden oder in einem Solarium suntanning. Leider küsste die Sonne Glut der Haut, die die meisten Menschen
- Ich bekam eine Nachricht von meinem Buch Publizist, der unerbittlich und zivilisierten Mark Fortier, über eine interessante neue Studie. Hier ist , was die Anfrage sagte: "Eine neue Umfrage von Adecco ( http://bit.ly/9jvwdW ) stellt fest , dass mehr
- Der bewaffnete Konflikt bleibt das Haupthindernis für die Welt von dieser verheerenden Krankheit zu befreien. Credit: James Gordon, Los Angeles. Dieser Artikel wurde ursprünglich veröffentlicht unter das Gespräch . Die Publikation beigetragen den Art
- Fa-la-la-la-igitt! Die Weihnachtszeit ist eine stressige Zeit des Jahres für die meisten Menschen. Für diejenigen von uns, die das Rauchen zu beenden arbeiten, können die Feiertage besonders schwierig sein. Verwenden Sie diese Tipps, die Ihnen helfen
Anämie und Vitamin-B12-Mangel - was bedeutet diese Art der Anämie kommen und warum sehe ich blass?... Ich sehe soo blass? ----schneiden---- In Antwort auf Alabasta ... bei 2013.02.24 20.46 Nicht genug essen Lebensmittel, die Vitamin B12 enthalten. Eine vegetarische oder vegane Ernährung kann Mangel verursachen, weil Vitamin B12 nur in tierischen
- Die Befestigung des Defektes Mental Health System Lloyd I. Sederer, MD, und Steven S. Sharfstein, MD Martin war 20 Jahre alt, als er zum zweiten Mal verhaftet wurde. Als Reaktion auf akustische Halluzinationen, seine aggressive Verhalten Menschen auf
- Wird SUDAFED PE meinem Kopf helfen ziehen?
- Weiß jemand, warum es sporadisch?
- Neuros Medical meldet erste Ergebnisse aus der Studie von Schmerz-Sperrvorrichtung
- Die Farm Bill Hackathon: Warum brauchen wir ein Mehr Zugänglich Dokument
- Melinda Gates pledges $560 million for contraception
- Gibt es finanzielle Unterstützung für Crestor, Cymbalta und Cyclobenzaprine?
- Keine Frage? Ein Update auf meinem PN?
- Zombie Apokalypse überleben Video gerade veröffentlicht: Wie man einen Impfstoff Zombie Spot (Satire)
- U.S. inspectors find further anthrax violations, mishandling
- Hypothyroidsm, TSH 17.6 Was kann ich erwarten?